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Schizophrenia is a chronic and severe mental disorder characterized by pervasive impairments in cognition, emotion, perception, and social functioning. Long-term use of antipsychotic medication is typically required to manage symptoms, prevent relapse, and reduce the risk of hospitalization [1-3].
J Med Internet Res 2026;28:e59175
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Reference 10: Schizophrenia commission report Reference 18: Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrumschizophrenia
JMIR Hum Factors 2025;12:e75377
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In clinical practice, heterogeneous symptoms and signs are grouped in clusters to define categorical diagnoses of psychotic disorders (schizophrenia or bipolar disorder) that are used as invariant labels chronically attached to patients, guiding clinical decisions. The shortcomings of such an approach in capturing the dynamic nature of psychotic disorders have been widely recognized [1].
JMIR Ment Health 2025;12:e75774
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In the current simulated patient program at the University of Oldenburg, the clinical picture of schizophrenia is also practiced with acting patients. Existing records of acting patients enabled the robot to reconstruct patient behavior. In collaboration with colleagues from the Department of Psychiatry, the clinical picture of schizophrenia was selected as a clinical case study for the robot simulated patient in our training scenario.
JMIR Form Res 2025;9:e70363
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Delusional Experiences Emerging From AI Chatbot Interactions or “AI Psychosis”
In phenomenological psychiatry, psychosis and schizophrenia are not seen mainly as collections of hallucinations or delusions, but as changes in the person’s relation to self and world [1]. This process, sometimes called desubjectivation (or de-embodiment of subjectivity), weakens the basic sense of being present to oneself and makes experience lose its immediacy [2,3]. Losing contact with reality means not only misperceiving things but feeling detached from what is real.
JMIR Ment Health 2025;12:e85799
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Hearing voices (auditory verbal hallucinations) is a phenomenon occurring in the general population, across various disorders, and commonly associated with psychosis or schizophrenia spectrum disorder diagnoses [1-4]. Voices may be highly distressing [5], especially due to appraisals of the meaning and intent of voices [6] and negative content [7,8].
Within psychosis, an estimated 1 in 3 individuals have a suboptimal pharmacological treatment response [9,10] with side effects being common [11].
JMIR Serious Games 2025;13:e77920
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Schizophrenia is a complex psychiatric condition with a large disease burden and is one of the top causes of disability globally, presenting considerable challenges for patients, caregivers, and health care systems [1-4]. In the United States, people living with schizophrenia have a severely reduced life expectancy (losing ≈28.5 years of life) [5] and significantly higher mortality rate [6] than the general population.
JMIR Res Protoc 2025;14:e81293
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Schizophrenia can lead to high functional disability and is associated with a heavy economic burden worldwide. The World Health Organization lists it as one of the top 10 conditions in terms of the global burden of disease [1,2]. Schizophrenia is a disease characterized by impairments in cognitive functions.
JMIR Serious Games 2025;13:e69116
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Psychotic illnesses such as schizophrenia and related conditions are a major issue for public health care systems; they cause severe disability and are expensive to treat. As the illness becomes manifest during adolescence or young adulthood, nonspecific signs such as anxiety, depression, and emerging psychotic features form a prelude to the full psychotic syndrome that may last for months or even years before patients seek help or receive treatment.
JMIR Res Protoc 2025;14:e74408
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Participants were eligible if they were aged 18‐40 and had experienced a FEP in the 24 months prior to entering the study as defined by a DSM-IV diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder, or delusional disorder based on the Structured Clinical Interview for DSM-IV (SCID-I) [22]. Finally, participants were required to have access to a smartphone with internet data.
J Med Internet Res 2025;27:e71989
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