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A Multilevel Network Peer Intervention Among Student Men Who Have Sex With Men Attending University: Protocol for an Implementation-Effectiveness Before-After Cohort Study

A Multilevel Network Peer Intervention Among Student Men Who Have Sex With Men Attending University: Protocol for an Implementation-Effectiveness Before-After Cohort Study

There is growing evidence that online interventions can effectively reduce HIV risk behaviors and promote HIV testing among MSM populations [9,10]. These findings underscore the potential of digital strategies in reducing HIV or sexually transmitted infection (STI) disparities among student MSM. Given this, it is crucial to evaluate the effectiveness of internet-based intervention programs in this population.

Jingpei Xu, Zhen Dai, Yushu Qiu, Liang Wang

JMIR Res Protoc 2026;15:e77078


A Complex Digital Health Intervention to Support People With HIV: Organizational Readiness Survey Study and Preimplementation Planning for a Hybrid Effectiveness-Implementation Study

A Complex Digital Health Intervention to Support People With HIV: Organizational Readiness Survey Study and Preimplementation Planning for a Hybrid Effectiveness-Implementation Study

It was developed and refined following a rigorous, iterative process of user-centered design to support people with HIV receiving outpatient care [15]. Program implementation among a cohort in Central Virginia where the intervention was developed and refined has demonstrated long-term usage and significant improvement in clinical outcomes at 1 [16], 2 [17], and 3 years [18]. The platform has been adapted for other chronic conditions, end users, and contexts [19-24].

Jacqueline Hodges, Wendy Cohn, Amanda Castel, Tabor Flickinger, Ava Lena Waldman, Michelle Hilgart, Olivia Kirby, Sylvia Caldwell, Karen Ingersoll

J Med Internet Res 2026;28:e76327


Support Community Formation on a Mobile App for People Living With HIV and Substance Use Disorder: A Computer-Mediated Discourse Analysis

Support Community Formation on a Mobile App for People Living With HIV and Substance Use Disorder: A Computer-Mediated Discourse Analysis

The HIV infection is highly prevalent among people who use drugs and alcohol. Among an estimated 8.9 to 22.4 million people who inject drugs globally, approximately 0.9 to 4.8 million are HIV positive [1]. Additionally, alcohol dependence is found in 40% to 50% of individuals living with HIV, and rates of cannabis and stimulant use are also higher among people living with HIV compared to the general population [2,3].

Adati Tarfa, Kristen Pecanac, Olayinka Shiyanbola, Cameron Liebert, Sarah Dietz, Rebecca Miller, Ryan P Westergaard

JMIR Form Res 2026;10:e66564


Interactive Internet-Based Motivational Interviewing Training for HIV Counseling Support Staff to Improve Health Communication in HIV Care Interactions: Protocol for Training Development and a Pilot Randomized Controlled Trial

Interactive Internet-Based Motivational Interviewing Training for HIV Counseling Support Staff to Improve Health Communication in HIV Care Interactions: Protocol for Training Development and a Pilot Randomized Controlled Trial

HIV counseling support staff (CSS) provide key services for HIV care outcomes, such as HIV test counseling, linkage to care, adherence counseling, peer support, and care navigation. Interventions delivered by CSS have increased HIV prevention [1,2], testing [3], linkage to care [4,5], treatment engagement [6], and adherence [4-7].

Iván C Balán, Onna R Brewer, Bryan A Kutner, Rebecca Giguere

JMIR Res Protoc 2026;15:e82241


Effectiveness and Implementation of Adapted Physical Activity Delivery Strategies for Older Adults Living With HIV in Ivory Coast: Protocol for a Type 2 Hybrid Randomized Controlled Trial

Effectiveness and Implementation of Adapted Physical Activity Delivery Strategies for Older Adults Living With HIV in Ivory Coast: Protocol for a Type 2 Hybrid Randomized Controlled Trial

With the scale-up of antiretroviral therapy (ART), the life expectancy of people living with HIV has improved dramatically over the last few decades, and HIV has become a chronic disease [1]. However, chronic HIV infection is associated with several long-term health challenges [2].

Nicolas Diadhiou, Nelly Assoumou, Joseph Tegbe, Herve Etchin Boa, Marie-Laura Bao, Simon Amador-Paz, Damien Vitiello, Patrick Coffie, Pierre Debeaudrap

JMIR Res Protoc 2026;15:e84677


Applications of Machine Learning for Cognitive Health in Older Individuals With HIV: Rapid Systematic Review

Applications of Machine Learning for Cognitive Health in Older Individuals With HIV: Rapid Systematic Review

Globally, there were approximately 39.9 million individuals living with HIV at the end of 2023 [1]. With advances in antiretroviral therapy, people with HIV are living longer, and more than 53% of them in the United States are now older than 50 years [2]. Although “older adults” commonly refers to individuals aged 65 years and above, research in the context of HIV often considers aging-related health concerns to emerge earlier due to accelerated and accentuated aging processes.

Hwayoung Cho, Jiyoun Song, Hannah Cho, Lin Li, Renjie Liang, Railton Miranda, Qianqian Song, Jiang Bian

JMIR Aging 2025;8:e80433


Feasibility and Usability of an mHealth App (mLab+) to Guide Users Through HIV and Syphilis Self-Testing: Pilot Randomized Controlled Trial

Feasibility and Usability of an mHealth App (mLab+) to Guide Users Through HIV and Syphilis Self-Testing: Pilot Randomized Controlled Trial

HIV self-testing is recommended for diverse populations worldwide [1] and is considered an important strategy in the US Ending the HIV Epidemic initiative [2,3]. HIV self-tests can facilitate access to antiretroviral therapy, HIV preexposure prophylaxis (Pr EP), and other prevention services [4,5].

Maeve Brin, Thomas F Scherr, Janejira Chaiyasit, Jianfang Liu, Maura Abbott, Robert Garofalo, Lisa M Kuhns, Tess Sky, Ian Esliker, Rebecca Schnall

JMIR Form Res 2025;9:e72955


Community-Based Adaptation and Evaluation of a Peer-Led Intervention to Address Alcohol Use and HIV in Pregnant and Breastfeeding Women in South Africa: Protocol for the “Mentor Mothers Plus” Randomized Control Trial

Community-Based Adaptation and Evaluation of a Peer-Led Intervention to Address Alcohol Use and HIV in Pregnant and Breastfeeding Women in South Africa: Protocol for the “Mentor Mothers Plus” Randomized Control Trial

Qualitative work contextualized these findings, suggesting that alcohol use, HIV risk behaviors, nonadherence to HIV treatment, and experiences of intimate partner violence (IPV) are all inextricably linked health issues [9,10]. Despite the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization’s (WHO) 2025 targets to eliminate vertical HIV transmission (defined as Despite these risks, community-informed interventions targeting both HIV and alcohol use among PLW are lacking.

Zaynab Essack, Zaino Petersen, Amanda P Miller, Sarah Schoetz Dean, Danielle Daniels, Hayley Hofmeester, Thomas Belin, Heidi van Rooyen, Jaco Louw, Dvora Joseph Davey

JMIR Res Protoc 2025;14:e78856


Development of an Ecological Momentary Assessment Study to Identify Real-Time Predictors of Physical Activity Among Older People With HIV: Protocol for a 2-Phase Mixed Methods Study

Development of an Ecological Momentary Assessment Study to Identify Real-Time Predictors of Physical Activity Among Older People With HIV: Protocol for a 2-Phase Mixed Methods Study

This paper describes the rationale and design of an ecological momentary assessment (EMA) study to improve understanding of physical activity (PA) among older people with HIV. By capturing within-person, time-varying factors that influence the daily PA levels of older people with HIV, it is anticipated that the study will offer novel insights into predicting PA behavior among older people with HIV.

Dan Song, Lisa Hightow-Weidman, Tuzhen Xu, Yijiong Yang, Jing Wang

JMIR Res Protoc 2025;14:e81238


A Mobile Game Intervention for Young Persons Living With HIV and Depression in Nigeria: Protocol for a Pilot Randomized Controlled Trial

A Mobile Game Intervention for Young Persons Living With HIV and Depression in Nigeria: Protocol for a Pilot Randomized Controlled Trial

Approximately 10% of the world’s 4 million young people, aged 15-24 years, living with HIV reside in Nigeria—an African nation with the fourth largest global population of people living with HIV [1-3]. Young people living with HIV also bear a disproportionate burden of depression compared to the general population, which is a key driver of poor HIV outcomes such as higher rates of interruptions in care, medication nonadherence, virologic failure, and progression of HIV [4-7].

Caleb Eliazer, Temitope Omotosho, Kehinde M Kuti, Leslie J Pierce, Dalton Gray, Carolyn M Audet, Olutosin Awolude, Oye Gureje, Bibilola Oladeji, Aima A Ahonkhai

JMIR Res Protoc 2025;14:e74199